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Target
Gastrin-releasing peptide receptor
Ligand
BDBM50112639
Substrate
n/a
Meas. Tech.
ChEMBL_39620 (CHEMBL649928)
IC50
1.1±n/a nM
Citation
 Achilefu, S; Jimenez, HN; Dorshow, RB; Bugaj, JE; Webb, EG; Wilhelm, RR; Rajagopalan, R; Johler, J; Erion, JL Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents. J Med Chem 45:2003-15 (2002) [PubMed]  Article 
Target
Name:
Gastrin-releasing peptide receptor
Synonyms:
GRPR_RAT | Gastrin-Releasing peptide | Gastrin-releasing peptide receptor | Grpr
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43227.55
Organism:
RAT
Description:
Gastrin-Releasing peptide 0 RAT::P52500
Residue:
384
Sequence:
MDPNNCSHLNLEVDPFLSCNNTFNQTLSPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV
  
Inhibitor
Name:
BDBM50112639
Synonyms:
CHEMBL402688 | pQ-Q-R-Y-G-N-Q-W-A-V-G-H-L-M-NH2
Type:
Small organic molecule
Emp. Form.:
C74H108N24O19S
Mol. Mass.:
1669.864
SMILES:
CSCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)CNC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCC(N)=O)NC(=O)C1CCC(=O)N1)C(C)C)C(N)=O
Structure:
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