Reaction Details Report a problem with these data
Target
Glutamate receptor 4
Ligand
BDBM50112778
Substrate
n/a
Meas. Tech.
ChEMBL_72848 (CHEMBL680873)
EC50
130±n/a nM
Citation
Shepherd, TA; Aikins, JA; Bleakman, D; Cantrell, BE; Rearick, JP; Simon, RL; Smith, EC; Stephenson, GA; Zimmerman, DM; Mandelzys, A; Jarvie, KR; Ho, K; Deverill, M; Kamboj, RK Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors. J Med Chem 45:2101-11 (2002) [PubMed] Article
More Info.:
Target
Name:
Glutamate receptor 4
Synonyms:
GLUR4 | GRIA4 | GRIA4_HUMAN | Glutamate receptor AMPA 3/4 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 4
Type:
PROTEIN
Mol. Mass.:
100881.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_468628
Residue:
902
Sequence:
MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP
Inhibitor
Name:
BDBM50112778
Synonyms:
(+/-) Propane-2-sulfonic acid [2-(4-bromo-phenyl)-cyclopentyl]-amide | (1S,2R) Propane-2-sulfonic acid [2-(4-bromo-phenyl)-cyclopentyl]-amide | CHEMBL304375
Type:
Small organic molecule
Emp. Form.:
C14H20BrNO2S
Mol. Mass.:
346.283
SMILES:
CC(C)S(=O)(=O)N[C@H]1CCC[C@@H]1c1ccc(Br)cc1