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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50112948
Substrate
n/a
Meas. Tech.
ChEBML_221484
IC50
6.2±n/a nM
Citation
 Chen, P; Norris, D; Iwanowicz, EJ; Spergel, SH; Lin, J; Gu, HH; Shen, Z; Wityak, J; Lin, TA; Pang, S; De Fex, HF; Pitt, S; Shen, DR; Doweyko, AM; Bassolino, DA; Roberge, JY; Poss, MA; Chen, BC; Schieven, GL; Barrish, JC Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett 12:1361-4 (2002) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50112948
Synonyms:
(4-(2-chloro-6-methylphenylamino)-6,7-dimethoxyimidazo[1,5-a]quinoxalin-1-yl)methanol | CHEMBL280546 | [4-(2-Chloro-6-methyl-phenylamino)-6,7-dimethoxy-imidazo[1,5-a]quinoxalin-1-yl]-methanol
Type:
Small organic molecule
Emp. Form.:
C20H19ClN4O3
Mol. Mass.:
398.843
SMILES:
COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(CO)n23)c1OC
Structure:
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