Reaction Details Report a problem with these data
Target
Sorbitol dehydrogenase
Ligand
BDBM50113493
Substrate
n/a
Meas. Tech.
ChEMBL_201007 (CHEMBL801928)
IC50
18±n/a nM
Citation
Chu-Moyer, MY; Ballinger, WE; Beebe, DA; Coutcher, JB; Day, WW; Li, J; Oates, PJ; Weekly, RM SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711. Bioorg Med Chem Lett 12:1477-80 (2002) [PubMed] Article
More Info.:
Target
Name:
Sorbitol dehydrogenase
Synonyms:
DHSO_RAT | Sdh1 | Sord
Type:
PROTEIN
Mol. Mass.:
38239.67
Organism:
Rattus norvegicus
Description:
ChEMBL_223914
Residue:
357
Sequence:
MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGPMVKHLKPGDRVAIEPGVPREIDEFCKIGRYNLTPSIFFCATPPDDGNLCRFYKHSADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPIGIVTLLVAKAMGASQVVVIDLSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVLGSKPEVTIECTGAESSVQTGIYATHSGGTLVVVGMGPEMINLPLVHAAVREVDIKGVFRYCNTWPMAVSMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGLGLKVMIKCDPNDQNP
Inhibitor
Name:
BDBM50113493
Synonyms:
1-(4-{(3S,5R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-pyrimidin-2-yl)-ethanone | CHEMBL286539
Type:
Small organic molecule
Emp. Form.:
C18H24N6O2
Mol. Mass.:
356.4222
SMILES:
C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)C(C)=O