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Target
Dipeptidyl peptidase 4
Ligand
BDBM50113678
Substrate
n/a
Meas. Tech.
ChEMBL_53366 (CHEMBL666612)
IC50
12000±n/a nM
Citation
 Villhauer, EB; Brinkman, JA; Naderi, GB; Dunning, BE; Mangold, BL; Mone, MD; Russell, ME; Weldon, SC; Hughes, TE 1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem 45:2362-5 (2002) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 4
Synonyms:
ACT3 | ADCP-I | Activation molecule 3 | Adenosine deaminase complexing protein | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_BOVIN | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | T-cell activation antigen CD26 | WC10
Type:
PROTEIN
Mol. Mass.:
88365.89
Organism:
Bos taurus
Description:
ChEMBL_849436
Residue:
765
Sequence:
MKTPWKVLLGLLAIAALVTVITVPVVLLTKGNDASTDSRRTYTLADYLKNTFRMKFYNLRWVSDHEYLYKQENNILLFNAEYGNSSIFLENSTFDEFGHSINDYSVSPDRQYILFEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSSVGHKLAYVWNNDIYVKNEPNSPSQRITWTGKKDVIYNGITDWVYEEEVFSAYSALWWSPNSTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVKIPYPKAGAVNPTIKFFVVNISSLSPNINATSQQIVPPGSVLIGDHYLCDVTWVTEERISLQWLRRIQNYSIMDICDYDRSTGRWISSVGRQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQTDKRNCTFITKGAWEVIGIEALTSDYLYYISNEYKGMPGARNLYKIQLNDYTKVTCLSCELNPDRCQYYSVSFSQEAKYYQLRCSGPGLPLYTLHNSNNDKELRVLENNSDLDQVLQDVQMPSKKLDFIHLHGTKFWYQMILPPHFDKSKKYPLLLEVYAGPCSQKADAIFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDSYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQSMWYTDEDHGIASSTAHQHIYTHMSHFLKQCFSLL
  
Inhibitor
Name:
BDBM50113678
Synonyms:
1-{2-[2-(5-Nitro-pyridin-2-ylamino)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile | CHEMBL77539
Type:
Small organic molecule
Emp. Form.:
C14H18N6O3
Mol. Mass.:
318.3311
SMILES:
[O-][N+](=O)c1ccc(NCCNCC(=O)N2CCC[C@H]2C#N)nc1
Structure:
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