Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50114534
Substrate
n/a
Meas. Tech.
ChEBML_212853
Ki
38±n/a nM
Citation
Czekaj, M; Klein, SI; Guertin, KR; Gardner, CJ; Zulli, AL; Pauls, HW; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Leadley, RJ; Dunwiddie, CT Optimization of the beta-aminoester class of factor Xa inhibitors. Part 1: P(4) and side-chain modifications for improved in vitro potency. Bioorg Med Chem Lett 12:1667-70 (2002) [PubMed] Article
More Info.:
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
Inhibitor
Name:
BDBM50114534
Synonyms:
(2R,3R)-3-[(3'-Aminomethyl-biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-methyl-hexanoic acid methyl ester | CHEMBL44831
Type:
Small organic molecule
Emp. Form.:
C30H36N4O3
Mol. Mass.:
500.6318
SMILES:
COC(=O)[C@H](Cc1cccc(c1)C(N)=N)[C@@H](CC(C)C)NC(=O)c1ccc(cc1)-c1cccc(CN)c1