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Target
Tyrosine-protein kinase CSK
Ligand
BDBM50114585
Substrate
n/a
Meas. Tech.
ChEMBL_210894 (CHEMBL814626)
IC50
41±n/a nM
Citation
 Calderwood, DJ; Johnston, DN; Munschauer, R; Rafferty, P Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck. Bioorg Med Chem Lett 12:1683-6 (2002) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase CSK
Synonyms:
C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK
Type:
Tyrosine-protein kinase
Mol. Mass.:
50707.30
Organism:
Homo sapiens (Human)
Description:
P41240
Residue:
450
Sequence:
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
  
Inhibitor
Name:
BDBM50114585
Synonyms:
(R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | CHEMBL47203
Type:
Small organic molecule
Emp. Form.:
C29H34N6O
Mol. Mass.:
482.6199
SMILES:
CN1CCN(CC1)[C@H]1CC[C@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |wU:7.7,10.14,(2.19,-10.22,;1.73,-8.75,;2.75,-7.59,;2.29,-6.14,;.77,-5.83,;-.26,-6.95,;.21,-8.41,;.3,-4.36,;-1.21,-4.04,;-1.67,-2.57,;-.63,-1.42,;.86,-1.75,;1.33,-3.22,;-1.1,.05,;-.19,1.28,;-1.1,2.52,;-.61,4.01,;-1.63,5.13,;-1.16,6.58,;.35,6.92,;.84,8.36,;2.34,8.68,;2.81,10.15,;4.32,10.44,;5.35,9.29,;4.88,7.84,;3.36,7.52,;1.38,5.76,;.89,4.29,;-2.56,2.05,;-3.89,2.82,;-3.89,4.36,;-5.22,2.05,;-5.23,.54,;-3.9,-.26,;-2.57,.51,)|
Structure:
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