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Target
Melatonin receptor type 1B
Ligand
BDBM50114707
Substrate
n/a
Meas. Tech.
ChEMBL_105250 (CHEMBL710586)
EC50
0.17±n/a nM
Citation
 Wallez, V; Durieux-Poissonnier, S; Chavatte, P; Boutin, JA; Audinot, V; Nicolas, JP; Bennejean, C; Delagrange, P; Renard, P; Lesieur, D Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands. J Med Chem 45:2788-800 (2002) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50114707
Synonyms:
But-3-enoic acid [2-(2-benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-amide | CHEMBL97186
Type:
Small organic molecule
Emp. Form.:
C22H23NO3
Mol. Mass.:
349.4229
SMILES:
COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CC=C)c2c1
Structure:
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