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Target
Dual specificity mitogen-activated protein kinase kinase 6
Ligand
BDBM50115295
Substrate
n/a
Meas. Tech.
ChEMBL_123998 (CHEMBL734026)
IC50
>30000±n/a nM
Citation
 Matsuno, K; Ichimura, M; Nakajima, T; Tahara, K; Fujiwara, S; Kase, H; Ushiki, J; Giese, NA; Pandey, A; Scarborough, RM; Lokker, NA; Yu, JC; Irie, J; Tsukuda, E; Ide, S; Oda, S; Nomoto, Y Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J Med Chem 45:3057-66 (2002) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 6
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3
Type:
Protein
Mol. Mass.:
37494.96
Organism:
Homo sapiens (Human)
Description:
P52564
Residue:
334
Sequence:
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
  
Inhibitor
Name:
BDBM50115295
Synonyms:
4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-nitro-phenyl)-amide | 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-nitro-phenyl)-amide(KN1022) | CHEMBL99743
Type:
Small organic molecule
Emp. Form.:
C21H22N6O5
Mol. Mass.:
438.4366
SMILES:
COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)[N+]([O-])=O)c2cc1OC
Structure:
Search PDB for entries with ligand similarity: