Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM50115621
Substrate
n/a
Meas. Tech.
ChEMBL_35527 (CHEMBL649553)
Ki
320±n/a nM
Citation
 Powers, RA; Shoichet, BK Structure-based approach for binding site identification on AmpC beta-lactamase. J Med Chem 45:3222-34 (2002) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC
Type:
Protien
Mol. Mass.:
41561.62
Organism:
Escherichia coli
Description:
P00811
Residue:
377
Sequence:
MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ
  
Inhibitor
Name:
BDBM50115621
Synonyms:
(2-(thiophen-2-yl)acetamido)methylboronic acid | Acylglycineboronic acid, 11 | CHEMBL320049 | N-2-THIOPHEN-2-YL-ACETAMIDE BORONIC ACID | N-dihydroxyBoranylmethyl-2-thiophen-2-yl-acetamide
Type:
Small organic molecule
Emp. Form.:
C7H10BNO3S
Mol. Mass.:
199.035
SMILES:
OB(O)CNC(=O)Cc1cccs1
Structure:
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