Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50115725
Substrate
n/a
Meas. Tech.
ChEBML_162256
IC50
270±n/a nM
Citation
 Ahn, JHCho, SYHa, JDChu, SYJung, SHJung, YSBaek, JYChoi, IKShin, EYKang, SKKim, SSCheon, HGYang, SDChoi, JK Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents. Bioorg Med Chem Lett 12:1941-6 (2002) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50115725
Synonyms:
3-(1-Indol-1-yl-3,4-dioxo-3,4-dihydro-naphthalen-2-yl)-propionic acid ethyl ester | CHEMBL61186
Type:
Small organic molecule
Emp. Form.:
C23H19NO4
Mol. Mass.:
373.4013
SMILES:
CCOC(=O)CCC1=C(c2ccccc2C(=O)C1=O)n1ccc2ccccc12 |t:7|
Structure:
Search PDB for entries with ligand similarity: