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Reaction Details
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TargetMelatonin receptor
LigandBDBM50118470
Substrate/Competitorn/a
Meas. Tech.ChEMBL_105243
Ki 0.0138±n/a nM
Citation Uchikawa, OFukatsu, KTokunoh, RKawada, MMatsumoto, KImai, YHinuma, SKato, KNishikawa, HHirai, KMiyamoto, MOhkawa, S Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists. J Med Chem45:4222-39 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melatonin receptor
Name:Melatonin receptor
Synonyms:MTNR1A | MTNR1A protein | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:Enzyme
Mol. Mass.:39392.94
Organism:Homo sapiens (Human)
Description:P48039
Residue:350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50118470
NameBDBM50118470
Synonyms:CHEMBL1218 | N-[2-(1,6,7,8-Tetrahydro-2H-3-oxa-as-indacen-8-yl)-ethyl]-propionamide(S)-(-)-22b | RAMELTEON | Rozerem
TypeSmall organic molecule
Emp. Form.C16H21NO2
Mol. Mass.259.3434
SMILESCCC(=O)NCC[C@@H]1CCc2ccc3OCCc3c12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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