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Target
Receptor-type tyrosine-protein phosphatase alpha
Ligand
BDBM50118762
Substrate
n/a
Meas. Tech.
ChEMBL_162603 (CHEMBL771315)
pH
5.5±n/a
Ki
290000±n/a nM
Comments
extracted
Citation
 Andersen, HS; Olsen, OH; Iversen, LF; Sørensen, AL; Mortensen, SB; Christensen, MS; Branner, S; Hansen, TK; Lau, JF; Jeppesen, L; Moran, EJ; Su, J; Bakir, F; Judge, L; Shahbaz, M; Collins, T; Vo, T; Newman, MJ; Ripka, WC; Møller, NP Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J Med Chem 45:4443-59 (2002) [PubMed]  Article 
Target
Name:
Receptor-type tyrosine-protein phosphatase alpha
Synonyms:
PTPA | PTPRA | PTPRA_HUMAN | PTPRL2 | Protein-tyrosine phosphatase alpha
Type:
Enzyme
Mol. Mass.:
90719.02
Organism:
Homo sapiens (Human)
Description:
P18433
Residue:
802
Sequence:
MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK
  
Inhibitor
Name:
BDBM50118762
Synonyms:
2-(Oxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid | 2-(carboxyformamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid | 2-oxalylamino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid | CHEMBL138152
Type:
Small organic molecule
Emp. Form.:
C11H11NO5S
Mol. Mass.:
269.274
SMILES:
OC(=O)C(=O)Nc1sc2CCCCc2c1C(O)=O
Structure:
Search PDB for entries with ligand similarity: