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Target
Procathepsin L
Ligand
BDBM50121040
Substrate
n/a
Meas. Tech.
ChEBML_48518
IC50
1.7±n/a nM
Citation
 Zhou, NE; Kaleta, J; Purisima, E; Menard, R; Micetich, RG; Singh, R 6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S. Bioorg Med Chem Lett 12:3417-9 (2002) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_RAT | Cathepsin L | Ctsl | Ctsl1
Type:
PROTEIN
Mol. Mass.:
37662.10
Organism:
Rattus norvegicus
Description:
ChEMBL_48517
Residue:
334
Sequence:
MTPLLLLAVLCLGTALATPKFDQTFNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHKKGRLFQEPLMLQIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIVN
  
Inhibitor
Name:
BDBM50121040
Synonyms:
CHEMBL117928 | [(S)-2-Pyridin-3-yl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C21H22N4O6S
Mol. Mass.:
458.488
SMILES:
O=C(N[C@@H](Cc1cccnc1)C(=O)N[C@H]1[C@H]2N(CCS2(=O)=O)C1=O)OCc1ccccc1
Structure:
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