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Target
Cathepsin B
Ligand
BDBM50121913
Substrate
n/a
Meas. Tech.
ChEBML_47599
IC50
13600±n/a nM
Citation
 Zhou, NE; Guo, D; Thomas, G; Reddy, AV; Kaleta, J; Purisima, E; Menard, R; Micetich, RG; Singh, R 3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors. Bioorg Med Chem Lett 13:139-41 (2002) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
CATB_RAT | Ctsb
Type:
Protein
Mol. Mass.:
37463.53
Organism:
Rattus norvegicus
Description:
P00787
Residue:
339
Sequence:
MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF
  
Inhibitor
Name:
BDBM50121913
Synonyms:
CHEMBL281518 | [(S)-1-((R)-2-Oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C20H21N3O4
Mol. Mass.:
367.3984
SMILES:
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1CNC1=O)OCc1ccccc1
Structure:
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