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Target
Sphingomyelin phosphodiesterase 2
Ligand
BDBM50122310
Substrate
n/a
Meas. Tech.
ChEMBL_144774 (CHEMBL751441)
IC50
377000±n/a nM
Citation
 Yokomatsu, T; Murano, T; Akiyama, T; Koizumi, J; Shibuya, S; Tsuji, Y; Soeda, S; Shimeno, H Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity. Bioorg Med Chem Lett 13:229-36 (2002) [PubMed]  Article 
Target
Name:
Sphingomyelin phosphodiesterase 2
Synonyms:
Lyso-PAF-PLC | Lyso-platelet-activating factor-phospholipase C | N-SMase | NSMA_HUMAN | Neutral sphingomyelinase | SMPD2 | Sphingomyelin phosphodiesterase 2 | nSMase
Type:
PROTEIN
Mol. Mass.:
47650.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_144777
Residue:
423
Sequence:
MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ
  
Inhibitor
Name:
BDBM50122310
Synonyms:
((2R,3R,4R)-1,1-Difluoro-3-hexadecanoylamino-2,4-dihydroxy-4-phenyl-butyl)-phosphonic acid | CHEMBL419642
Type:
Small organic molecule
Emp. Form.:
C26H44F2NO6P
Mol. Mass.:
535.6012
SMILES:
CCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)c1ccccc1)[C@@H](O)C(F)(F)P(O)(O)=O
Structure:
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