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Target
Sphingomyelin phosphodiesterase 2
Ligand
BDBM50100341
Substrate
n/a
Meas. Tech.
ChEMBL_144774 (CHEMBL751441)
IC50
1000±n/a nM
Citation
 Yokomatsu, T; Murano, T; Akiyama, T; Koizumi, J; Shibuya, S; Tsuji, Y; Soeda, S; Shimeno, H Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity. Bioorg Med Chem Lett 13:229-36 (2002) [PubMed]  Article 
Target
Name:
Sphingomyelin phosphodiesterase 2
Synonyms:
Lyso-PAF-PLC | Lyso-platelet-activating factor-phospholipase C | N-SMase | NSMA_HUMAN | Neutral sphingomyelinase | SMPD2 | Sphingomyelin phosphodiesterase 2 | nSMase
Type:
PROTEIN
Mol. Mass.:
47650.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_144777
Residue:
423
Sequence:
MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ
  
Inhibitor
Name:
BDBM50100341
Synonyms:
(2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl-hexadeca-2,4,6,12-tetraenoic acid [(S)-1-hydroxymethyl-2-((1S,2S,6S)-2-hydroxy-3-oxo-7-oxa-bicyclo[4.1.0]hept-4-en-2-yl)-ethyl]-amide | CHEMBL418376
Type:
Small organic molecule
Emp. Form.:
C29H43NO5
Mol. Mass.:
485.6554
SMILES:
CC[C@@H](C)\C=C(/C)C[C@@H](C)C[C@@H](C)\C=C\C=C\C=C\C(=O)N[C@H](CO)C[C@]1(O)[C@H]2O[C@H]2C=CC1=O |c:32|
Structure:
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