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Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50123335
Substrate
n/a
Meas. Tech.
ChEMBL_89814 (CHEMBL698781)
IC50
<5±n/a nM
Citation
 Watterson, SH; Carlsen, M; Dhar, TG; Shen, Z; Pitts, WJ; Guo, J; Gu, HH; Norris, D; Chorba, J; Chen, P; Cheney, D; Witmer, M; Fleener, CA; Rouleau, K; Townsend, R; Hollenbaugh, DL; Iwanowicz, EJ Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series. Bioorg Med Chem Lett 13:543-6 (2003) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55806.87
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH2 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50123335
Synonyms:
2-(3,4-Dimethyl-phenyl)-7-methoxy-6-oxazol-5-yl-1H-quinolin-4-one | CHEMBL358876
Type:
Small organic molecule
Emp. Form.:
C21H18N2O3
Mol. Mass.:
346.3792
SMILES:
COc1cc2nc(cc(O)c2cc1-c1cnco1)-c1ccc(C)c(C)c1
Structure:
Search PDB for entries with ligand similarity: