Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50451763
Substrate
n/a
Meas. Tech.
ChEMBL_106182 (CHEMBL714601)
EC50
8±n/a nM
Citation
 Danho, W; Swistok, J; Cheung, AW; Kurylko, G; Franco, L; Chu, XJ; Chen, L; Yagaloff, K Structure-activity relationship of linear peptide Bu-His6-DPhe7-Arg8-Trp9-Gly10-NH2 at the human melanocortin-1 and -4 receptors: DPhe7 and Trp9 substitution. Bioorg Med Chem Lett 13:649-52 (2003) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50451763
Synonyms:
CHEMBL2112919
Type:
Small organic molecule
Emp. Form.:
C36H48N12O6S
Mol. Mass.:
776.908
SMILES:
CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1cccs1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O |wU:16.17,6.6,26.28,wD:37.39,(-1.74,-13.62,;-.6,-12.59,;-.92,-11.08,;.22,-10.06,;1.68,-10.52,;-.11,-8.55,;1.03,-7.52,;.73,-6.01,;1.87,-4.99,;3.37,-5.31,;4.14,-3.98,;3.12,-2.82,;1.71,-3.45,;2.51,-7.99,;2.82,-9.5,;3.65,-6.96,;5.12,-7.44,;5.43,-8.96,;6.89,-9.43,;7.37,-10.89,;8.92,-10.89,;9.38,-9.42,;8.14,-8.51,;6.26,-6.41,;5.94,-4.91,;7.72,-6.89,;8.86,-5.86,;8.55,-4.35,;9.69,-3.33,;9.37,-1.82,;10.51,-.79,;10.19,.71,;11.34,1.74,;8.73,1.2,;10.33,-6.34,;10.64,-7.84,;11.48,-5.31,;12.93,-5.78,;13.26,-7.29,;14.73,-7.75,;15.97,-6.85,;17.21,-7.75,;16.73,-9.22,;17.5,-10.56,;16.73,-11.89,;15.2,-11.89,;14.43,-10.56,;15.2,-9.22,;14.08,-4.75,;13.76,-3.24,;15.55,-5.22,;16.69,-4.2,;18.15,-4.68,;19.29,-3.64,;18.47,-6.17,)|
Structure:
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