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TargetMelanocyte-stimulating hormone receptor
LigandBDBM50124777
Substrate/Competitorn/a
Meas. Tech.ChEBML_105836
EC50 1±n/a nM
Citation Danho, WSwistok, JCheung, AWKurylko, GFranco, LChu, XJChen, LYagaloff, K Structure-activity relationship of linear peptide Bu-His6-DPhe7-Arg8-Trp9-Gly10-NH2 at the human melanocortin-1 and -4 receptors: DPhe7 and Trp9 substitution. Bioorg Med Chem Lett13:649-52 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocyte-stimulating hormone receptor
Name:Melanocortin receptor (M1 and M4)
Synonyms:MC1-R | MSH-R | Melanocortin MC1 | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:Enzyme
Mol. Mass.:34717.23
Organism:Homo sapiens (Human)
Description:Q01726
Residue:317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW
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BDBM50124777
NameBDBM50124777
Synonyms:(S)-2-{(S)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-(carbamoylmethyl-carbamoyl)-2-naphthalen-1-yl-ethyl]-amide | CHEMBL2112917
TypeSmall organic molecule
Emp. Form.C36H47Cl2N11O6
Mol. Mass.800.734
SMILESCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)NCC(N)=O |wU:6.6,16.17,27.29,wD:38.40,(-9.4,-5.78,;-8.08,-5.01,;-8.08,-3.47,;-6.73,-2.71,;-5.4,-3.47,;-6.73,-1.17,;-5.4,-.4,;-5.4,1.16,;-4.06,1.93,;-2.65,1.3,;-1.62,2.44,;-2.39,3.78,;-3.91,3.47,;-4.06,-1.17,;-4.06,-2.71,;-2.73,-.4,;-1.39,-1.17,;-1.39,-2.71,;-.05,-3.48,;1.28,-2.71,;2.62,-3.48,;2.62,-5.02,;1.28,-5.79,;-.05,-5.02,;-.05,-.4,;-.05,1.16,;1.28,-1.17,;2.62,-.4,;2.62,1.16,;3.95,1.93,;3.95,3.47,;5.29,4.24,;5.29,5.8,;6.63,6.55,;3.95,6.55,;3.95,-1.17,;3.95,-2.71,;5.29,-.4,;6.63,-1.17,;6.63,-2.71,;7.96,-3.48,;9.29,-2.71,;10.63,-3.47,;10.63,-5.02,;11.97,-5.79,;9.29,-5.81,;9.29,-7.35,;7.95,-5.02,;7.96,-.4,;7.96,1.16,;9.31,-1.17,;10.64,-.4,;11.97,-1.17,;13.3,-.4,;11.97,-2.71,)|
Structure
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