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Target
Methionine--tRNA ligase
Ligand
BDBM50124846
Substrate
n/a
Meas. Tech.
ChEMBL_105150 (CHEMBL716780)
IC50
3.8±n/a nM
Citation
 Jarvest, RL; Berge, JM; Brown, MJ; Brown, P; Elder, JS; Forrest, AK; Houge-Frydrych, CS; O'Hanlon, PJ; McNair, DJ; Rittenhouse, S; Sheppard, RJ Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity. Bioorg Med Chem Lett 13:665-8 (2003) [PubMed]  Article 
Target
Name:
Methionine--tRNA ligase
Synonyms:
Methionyl-tRNA synthetase | SYM_ECOLI | metG
Type:
PROTEIN
Mol. Mass.:
76245.79
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_400681
Residue:
677
Sequence:
MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPSNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYKTFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMRQVEALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDAGAKPGHQVK
  
Inhibitor
Name:
BDBM50124846
Synonyms:
2-[3-(5,7-Dichloro-1,2,3,4-tetrahydro-naphthalen-1-ylamino)-propylamino]-1H-quinolin-4-one | CHEMBL162534
Type:
Small organic molecule
Emp. Form.:
C22H23Cl2N3O
Mol. Mass.:
416.344
SMILES:
Oc1cc(NCCCNC2CCCc3c(Cl)cc(Cl)cc23)nc2ccccc12
Structure:
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