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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50125599
Substrate
n/a
Meas. Tech.
ChEBML_124636
IC50
510±n/a nM
Citation
 Wan, Z; Boehm, JC; Bower, MJ; Kassis, S; Lee, JC; Zhao, B; Adams, JL N-Phenyl-N-purin-6-yl ureas: the design and synthesis of p38alpha MAP kinase inhibitors. Bioorg Med Chem Lett 13:1191-4 (2003) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50125599
Synonyms:
1-(2,6-Difluoro-phenyl)-1-(9-methyl-2-phenyl-9H-purin-6-yl)-urea | CHEMBL18617
Type:
Small organic molecule
Emp. Form.:
C19H14F2N6O
Mol. Mass.:
380.3509
SMILES:
Cn1cnc2c(nc(nc12)-c1ccccc1)N(C(N)=O)c1c(F)cccc1F
Structure:
Search PDB for entries with ligand similarity: