Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPA/PB1
LigandBDBM50409783
Substrate/Competitorn/a
Meas. Tech.ChEMBL_64976
IC50 12±n/a nM
Citation Parkes, KEErmert, PFässler, JIves, JMartin, JAMerrett, JHObrecht, DWilliams, GKlumpp, K Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors. J Med Chem46:1153-64 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
PA/PB1
Name:PA/PB1
Synonyms:Hepatitis C virus polyprotein | Polymerase acidic protein | RNA-directed RNA polymerase subunit P2
Type:PROTEIN
Mol. Mass.:82573.84
Organism:Hepatitis C virus
Description:ChEMBL_64976
Residue:716
Sequence:
MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGES
IIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQ
EMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNG
YIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNM
KKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDS
SWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKY
CVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSA
ESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50409783
NameBDBM50409783
Synonyms:CHEMBL1626982 | CHEMBL2068710 | CHEMBL2068711 | CHEMBL2068712 | CHEMBL2068718 | CHEMBL2068732
TypeSmall organic molecule
Emp. Form.C23H22ClNO4
Mol. Mass.411.879
SMILES[O-]C(=O)C(=O)[CH-]C(=O)C1(Cc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a