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Target
Microsomal triglyceride transfer protein large subunit
Ligand
BDBM50126224
Substrate
n/a
Meas. Tech.
ChEBML_123010
IC50
470±n/a nM
Citation
 Magnin, DR; Biller, SA; Wetterau, J; Robl, JA; Dickson, JK; Taunk, P; Harrity, TW; Lawrence, RM; Sun, CQ; Wang, T; Logan, J; Fryszman, O; Connolly, F; Jolibois, K; Kunselman, L Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents. Bioorg Med Chem Lett 13:1337-40 (2003) [PubMed]  Article 
Target
Name:
Microsomal triglyceride transfer protein large subunit
Synonyms:
MTP | MTP_BOVIN | MTTP
Type:
PROTEIN
Mol. Mass.:
99049.43
Organism:
Bos taurus
Description:
ChEMBL_123010
Residue:
887
Sequence:
FLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVFLDRGKGNLQDSVGYRISSNVDVALLWRSPDGDDNQLIQITMKDVNLENVNQQRGEKSIFKGKKSSQIIRKENLEAMQRPVLLHLIHGKIKEFYSYQNEPAAIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCKIERAGFTTPHQVLGVTSKATSVTTYKIEDSFVVAVLSEEIRALRLNFLQSIAGKIVSRQKLELKTTEASVRLKPGKQVAAIIKAVDSKYTAIPIVGQVFQSKCKGCPSLSEHWQSIRKHLQPDNLSKAEAVRSFLAFIKHLRTAKKEEILQILKAENKEVLPQLVDAVTSAQTPDSLDAILDFLDFKSTESVILQERFLYACAFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNQGCKLKGVIEAKKLILGGLEKAEKKEDIVMYLLALKNARLPEGIPLLLKYTETGEGPISHLAATTLQRYDVPFITDEVKKTMNRIYHQNRKIHEKTVRTTAAAIILKNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFETPASKMVRQVLKEMVAHNYDRFSKSGSSSAYTGYVERTSHSASTYSLDILYSGSGILRRSNLNIFQYIEKTPLHGIQVVIEAQGLEALIAATPDEGEENLDSYAGLSALLFDVQLRPVTFFNGYSDLMSKMLSASSDPMSVVKGLLLLIDHSQELQLQSGLKANMDVQGGLAIDITGAMEFSLWYRESKTRVKNRVSVLITGGITVDSSFVKAGLEIGAETEAGLEFISTVQFSQYPFLVCLQMDKEDVPYRQFETKYERLSTGRGYISRKRKESLIGGCEFPLHQENSDMCKVVFAPQPESSSSGWF
  
Inhibitor
Name:
BDBM50126224
Synonyms:
(4-{9-[(Pyridin-2-ylmethyl)-carbamoyl]-9H-fluoren-9-yl}-butyl)-phosphonic acid dibutyl ester | CHEMBL26411
Type:
Small organic molecule
Emp. Form.:
C32H41N2O4P
Mol. Mass.:
548.6527
SMILES:
CCCCOP(=O)(CCCCC1(C(=O)NCc2ccccn2)c2ccccc2-c2ccccc12)OCCCC
Structure:
Search PDB for entries with ligand similarity: