Reaction Details Report a problem with these data
Target
Microsomal triglyceride transfer protein large subunit
Ligand
BDBM50126225
Substrate
n/a
Meas. Tech.
ChEBML_123010
IC50
25±n/a nM
Citation
Magnin, DR; Biller, SA; Wetterau, J; Robl, JA; Dickson, JK; Taunk, P; Harrity, TW; Lawrence, RM; Sun, CQ; Wang, T; Logan, J; Fryszman, O; Connolly, F; Jolibois, K; Kunselman, L Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents. Bioorg Med Chem Lett 13:1337-40 (2003) [PubMed] Article
More Info.:
Target
Name:
Microsomal triglyceride transfer protein large subunit
Synonyms:
MTP | MTP_BOVIN | MTTP
Type:
PROTEIN
Mol. Mass.:
99049.43
Organism:
Bos taurus
Description:
ChEMBL_123010
Residue:
887
Sequence:
FLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVFLDRGKGNLQDSVGYRISSNVDVALLWRSPDGDDNQLIQITMKDVNLENVNQQRGEKSIFKGKKSSQIIRKENLEAMQRPVLLHLIHGKIKEFYSYQNEPAAIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCKIERAGFTTPHQVLGVTSKATSVTTYKIEDSFVVAVLSEEIRALRLNFLQSIAGKIVSRQKLELKTTEASVRLKPGKQVAAIIKAVDSKYTAIPIVGQVFQSKCKGCPSLSEHWQSIRKHLQPDNLSKAEAVRSFLAFIKHLRTAKKEEILQILKAENKEVLPQLVDAVTSAQTPDSLDAILDFLDFKSTESVILQERFLYACAFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNQGCKLKGVIEAKKLILGGLEKAEKKEDIVMYLLALKNARLPEGIPLLLKYTETGEGPISHLAATTLQRYDVPFITDEVKKTMNRIYHQNRKIHEKTVRTTAAAIILKNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFETPASKMVRQVLKEMVAHNYDRFSKSGSSSAYTGYVERTSHSASTYSLDILYSGSGILRRSNLNIFQYIEKTPLHGIQVVIEAQGLEALIAATPDEGEENLDSYAGLSALLFDVQLRPVTFFNGYSDLMSKMLSASSDPMSVVKGLLLLIDHSQELQLQSGLKANMDVQGGLAIDITGAMEFSLWYRESKTRVKNRVSVLITGGITVDSSFVKAGLEIGAETEAGLEFISTVQFSQYPFLVCLQMDKEDVPYRQFETKYERLSTGRGYISRKRKESLIGGCEFPLHQENSDMCKVVFAPQPESSSSGWF
Inhibitor
Name:
BDBM50126225
Synonyms:
CHEMBL26665 | {4-[9-(2,2,2-Trifluoro-ethylcarbamoyl)-9H-fluoren-9-yl]-butyl}-phosphonic acid bis-(3-pyridin-2-yl-propyl) ester
Type:
Small organic molecule
Emp. Form.:
C36H39F3N3O4P
Mol. Mass.:
665.6815
SMILES:
FC(F)(F)CNC(=O)C1(CCCCP(=O)(OCCCc2ccccn2)OCCCc2ccccn2)c2ccccc2-c2ccccc12