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Target
Ribosomal protein S6 kinase alpha-5
Ligand
BDBM50126732
Substrate
n/a
Meas. Tech.
ChEMBL_103939 (CHEMBL714978)
IC50
>1000±n/a nM
Citation
 Goldberg, DR; Butz, T; Cardozo, MG; Eckner, RJ; Hammach, A; Huang, J; Jakes, S; Kapadia, S; Kashem, M; Lukas, S; Morwick, TM; Panzenbeck, M; Patel, U; Pav, S; Peet, GW; Peterson, JD; Prokopowicz, AS; Snow, RJ; Sellati, R; Takahashi, H; Tan, J; Tschantz, MA; Wang, XJ; Wang, Y; Wolak, J; Xiong, P; Moss, N Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase. J Med Chem 46:1337-49 (2003) [PubMed]  Article 
Target
Name:
Ribosomal protein S6 kinase alpha-5
Synonyms:
90 kDa ribosomal protein S6 kinase 5 | KS6A5_HUMAN | MSK1 | Mitogen- and Stress-Activated Protein Kinase 1 (MSK1) | Nuclear mitogen- and stress-activated protein kinase 1 | Nuclear mitogen- and stress-activated protein kinase 1 (MSK1) | RPS6KA5 | RPS6KA5(Kin.Dom.2 - C-terminal) | RSK-like protein kinase | RSKL | Ribosomal protein S6 kinase | Ribosomal protein S6 kinase alpha 5 | Ribosomal protein S6 kinase alpha-5
Type:
Serine/threonine-protein kinase
Mol. Mass.:
89874.44
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
802
Sequence:
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFSDSVA
  
Inhibitor
Name:
BDBM50126732
Synonyms:
2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-propenyl)-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one | CHEMBL281957
Type:
Small organic molecule
Emp. Form.:
C25H27Cl2N5O
Mol. Mass.:
484.421
SMILES:
CCN(CC)CC=Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1C |w:6.5|
Structure:
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