Target
Geranylgeranyl transferase type-1 subunit beta
Ligand
BDBM50127320
Substrate
n/a
Meas. Tech.
ChEBML_71806
IC50
830±n/a nM
Citation
 Tong, YLin, NHWang, LHasvold, LWang, WLeonard, NLi, TLi, QCohen, JGu, WZZhang, HStoll, VBauch, JMarsh, KRosenberg, SHSham, HL Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability. Bioorg Med Chem Lett 13:1571-4 (2003) [PubMed]  Article 
Target
Name:
Geranylgeranyl transferase type-1 subunit beta
Synonyms:
2.5.1.59 | GGTase-I-beta | Geranylgeranyl transferase type I | Geranylgeranyl transferase type I beta subunit | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGGT1B | PGTB1_HUMAN | Protein farnesyl/geranylgeranyl transferase | Type I protein geranyl-geranyltransferase subunit beta
Type:
n/a
Mol. Mass.:
42369.84
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
377
Sequence:
MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST
  
Inhibitor
Name:
BDBM50127320
Synonyms:
5'-(3-Chloro-phenyl)-6'-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile | CHEMBL38941
Type:
Small organic molecule
Emp. Form.:
C30H27ClN6O2
Mol. Mass.:
539.027
SMILES:
Cn1cncc1C(OCc1nc(N2CCC(O)CC2)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N
Structure:
Search PDB for entries with ligand similarity: