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Target
Kappa-type opioid receptor
Ligand
BDBM50127338
Substrate
n/a
Meas. Tech.
ChEBML_145961
Ki
481.0±n/a nM
Citation
 Pagé, D; Nguyen, N; Bernard, S; Coupal, M; Gosselin, M; Lepage, J; Adam, L; Brown, W New scaffolds in the development of mu opioid-receptor ligands. Bioorg Med Chem Lett 13:1585-9 (2003) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50127338
Synonyms:
(S)-3-(3-tert-Butyl-ureidomethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid (tetrahydro-furan-2-ylmethyl)-amide | CHEMBL289137
Type:
Small organic molecule
Emp. Form.:
C21H32N4O2S
Mol. Mass.:
404.569
SMILES:
CC(C)(C)NC(=O)NC[C@@H]1Cc2ccccc2CN1C(=S)NCC1CCCO1
Structure:
Search PDB for entries with ligand similarity: