Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50127341
Substrate
n/a
Meas. Tech.
ChEBML_145961
Ki
480±n/a nM
Citation
 Pagé, D; Nguyen, N; Bernard, S; Coupal, M; Gosselin, M; Lepage, J; Adam, L; Brown, W New scaffolds in the development of mu opioid-receptor ligands. Bioorg Med Chem Lett 13:1585-9 (2003) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50127341
Synonyms:
(S)-3-(3-tert-Butyl-ureidomethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid ((R)-1-benzyl-pyrrolidin-2-ylmethyl)-amide | CHEMBL40825
Type:
Small organic molecule
Emp. Form.:
C28H39N5OS
Mol. Mass.:
493.707
SMILES:
CC(C)(C)NC(=O)NC[C@@H]1Cc2ccccc2CN1C(=S)NC[C@H]1CCCN1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: