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Target
Cholesteryl ester transfer protein
Ligand
BDBM50128131
Substrate
n/a
Meas. Tech.
ChEMBL_216900 (CHEMBL815633)
IC50
0.77±n/a nM
Citation
 Reinhard, EJ; Wang, JL; Durley, RC; Fobian, YM; Grapperhaus, ML; Hickory, BS; Massa, MA; Norton, MB; Promo, MA; Tollefson, MB; Vernier, WF; Connolly, DT; Witherbee, BJ; Melton, MA; Regina, KJ; Smith, ME; Sikorski, JA Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein. J Med Chem 46:2152-68 (2003) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50128131
Synonyms:
(R)-3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(4-chloro-3-ethylphenoxy)phenyl)amino)-1,1,1-trifluoropropan-2-ol | (R)-3-((3-(4-chloro-3-ethylphenoxy)phenyl)(3-(1,1,2,2-tetrafluoroethoxy)benzyl)amino)-1,1,1-trifluoropropan-2-ol | 3-{[3-(4-Chloro-3-ethyl-phenoxy)-phenyl]-[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-amino}-1,1,1-trifluoro-propan-2-ol | CHEMBL67129 | SC-795
Type:
Small organic molecule
Emp. Form.:
C26H23ClF7NO3
Mol. Mass.:
565.908
SMILES:
CCc1cc(Oc2cccc(c2)N(C[C@@H](O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)ccc1Cl
Structure:
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