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Target
Glutamate receptor 1
Ligand
BDBM50017244
Substrate
n/a
Meas. Tech.
ChEMBL_90146 (CHEMBL701244)
EC50
14000±n/a nM
Citation
 Bjerrum, EJ; Kristensen, AS; Pickering, DS; Greenwood, JR; Nielsen, B; Liljefors, T; Schousboe, A; Bräuner-Osborne, H; Madsen, U Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J Med Chem 46:2246-9 (2003) [PubMed]  Article 
Target
Name:
Glutamate receptor 1
Synonyms:
GRIA1_MOUSE | Glur1 | Glutamate receptor ionotropic, AMPA | Glutamate receptor ionotropic, AMPA 1 | Gria1
Type:
PROTEIN
Mol. Mass.:
101574.96
Organism:
Mus musculus
Description:
ChEMBL_90145
Residue:
907
Sequence:
MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGGSGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGATGL
  
Inhibitor
Name:
BDBM50017244
Synonyms:
(R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)propionic acid | 2-Amino-3-(4-bromo-3-hydroxy-isoxazol-5-yl)-propionic acid | CHEMBL73698
Type:
Small organic molecule
Emp. Form.:
C6H7BrN2O4
Mol. Mass.:
251.035
SMILES:
NC(Cc1o[nH]c(=O)c1Br)C(O)=O
Structure:
Search PDB for entries with ligand similarity: