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TargetEcdysone receptor
LigandBDBM50128308
Substrate/Competitorn/a
Meas. Tech.ChEMBL_65456
EC50 15000±n/a nM
Citation Tice, CMHormann, REThompson, CSFriz, JLCavanaugh, CKSaggers, JA Optimization of alpha-acylaminoketone ecdysone agonists for control of gene expression. Bioorg Med Chem Lett13:1883-6 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Ecdysone receptor
Name:Ecdysone receptor
Synonyms:20-hydroxy-ecdysone receptor | 20E receptor | EcRH | Ecdysteroid receptor | Nuclear receptor subfamily 1 group H member 1
Type:PROTEIN
Mol. Mass.:68199.29
Organism:Bombyx mori
Description:ChEMBL_65456
Residue:606
Sequence:
MRVENVDNVSFALNGRADEWCMSVETRLDSLVREKSEVKAYVGGCPSVITDAGAYDALFD
MRRRWSNNGGFPLRMLEESSSEVTSSSALGLPPAMVMSPESLASPEYRALELWSYDDGIT
YNTAQSLLGACNMQQQQLQPQQPHPAPPTLPTMPLPMPPTTPKSENESMSSGREELSPAS
SINGCSADADARRQKKGPAPRQQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAV
YICKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVIQEPSKNKDRQRQKKDKGILLPV
STTTVEDHMPPIMQCDPPPPEAARIHEVVPRYLSEKLMEQNRQKNIPPLSANQKSLIARL
VWYQEGYEQPSDEDLKRVTQTWQSDEEDEESDLPFRQITEMTILTVQLIVEFAKGLPGFS
KISQSDQITLLKASSSEVMMLRVARRYDAASDSVLFANNKAYTRDNYRQGGMAYVIEDLL
HFCRCMFAMGMDNVHFALLTAIVIFSDRPGLEQPSLVEEIQRYYLNTLRIYIINQNSASS
RCAVIYGRILSVLTELRTLGTQNSNMCISLKLKNRKLPPFLEEIWDVAEVATTHPTVLPP
TNPVVL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50128308
NameBDBM50128308
Synonyms:CHEMBL293929 | N-[4-(3,5-Dimethyl-benzoyl)-1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-yl]-3-methoxy-2-methyl-benzamide
TypeSmall organic molecule
Emp. Form.C23H27NO5S
Mol. Mass.429.529
SMILESCOc1cccc(C(=O)NC2(CCS(=O)(=O)CC2)C(=O)c2cc(C)cc(C)c2)c1C
Structure
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n/a