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Target
Insulin-like growth factor-binding protein 3
Ligand
BDBM50128431
Substrate
n/a
Meas. Tech.
ChEBML_90404
Ki
32±n/a nM
Citation
 Zhu, YF; Wilcoxen, K; Gross, T; Connors, P; Strack, N; Gross, R; Huang, CQ; McCarthy, JR; Xie, Q; Ling, N; Chen, C 6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain. Bioorg Med Chem Lett 13:1927-30 (2003) [PubMed]  Article 
Target
Name:
Insulin-like growth factor-binding protein 3
Synonyms:
IBP3 | IBP3_HUMAN | IGFBP3 | Insulin-like growth factor binding protein 3
Type:
PROTEIN
Mol. Mass.:
31690.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90404
Residue:
291
Sequence:
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
  
Inhibitor
Name:
BDBM50128431
Synonyms:
1-[3-Fluoro-4-(4-trifluoromethyl-phenoxy)-benzoyl]-6,7-dihydroxy-isoquinoline-3-carboxylic acid | CHEMBL57564
Type:
Small organic molecule
Emp. Form.:
C24H13F4NO6
Mol. Mass.:
487.3567
SMILES:
OC(=O)c1cc2cc(O)c(O)cc2c(n1)C(=O)c1ccc(Oc2ccc(cc2)C(F)(F)F)c(F)c1
Structure:
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