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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50128845
Substrate
n/a
Meas. Tech.
ChEMBL_226200 (CHEMBL843326)
IC50
140±n/a nM
Citation
 Ikuina, Y; Amishiro, N; Miyata, M; Narumi, H; Ogawa, H; Akiyama, T; Shiotsu, Y; Akinaga, S; Murakata, C Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol. J Med Chem 46:2534-41 (2003) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Proto-oncogene c-Src | SRC_RAT | Src | Tyrosine-protein kinase SRC | p60-Src | pp60c-src
Type:
PROTEIN
Mol. Mass.:
59976.76
Organism:
Rattus norvegicus
Description:
ChEMBL_453858
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGAFPASQTPSKPASADGHRGPNAAFVPPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50128845
Synonyms:
16-Chloro-17,19-dihydroxy-4-methyl-3,7-dioxa-tricyclo[13.4.0.0*6,8*]nonadeca-1(19),9,11,15,17-pentaene-2,13-dione 13-[O-(2-morpholin-4-yl-2-oxo-ethyl)-oxime] | CHEMBL82750
Type:
Small organic molecule
Emp. Form.:
C24H27ClN2O8
Mol. Mass.:
506.933
SMILES:
C[C@@H]1C[C@H]2O[C@@H]2\C=C/C=C/C(/Cc2c(Cl)c(O)cc(O)c2C(=O)O1)=N\OCC(=O)N1CCOCC1 |c:7,t:9|
Structure:
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