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Target
Calcium-activated potassium channel subunit alpha-1
Ligand
BDBM50128985
Substrate
n/a
Meas. Tech.
ChEBML_39096
EC50
3860±n/a nM
Citation
 Turner, SC; Carroll, WA; White, TK; Gopalakrishnan, M; Coghlan, MJ; Shieh, CC; Zhang, XF; Parihar, AS; Buckner, SA; Milicic, I; Sullivan, JP The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: synthesis and structure-activity relationships of 2-amino-4-azaindoles. Bioorg Med Chem Lett 13:2003-7 (2003) [PubMed]  Article 
Target
Name:
Calcium-activated potassium channel subunit alpha-1
Synonyms:
Calcium-activated potassium channel alpha/beta 1 | KCMA1_HUMAN | KCNMA | KCNMA1 | Large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b | SLO
Type:
PROTEIN
Mol. Mass.:
137567.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_938830
Residue:
1236
Sequence:
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL
  
Inhibitor
Name:
BDBM50128985
Synonyms:
2-Morpholin-4-yl-1H-pyrrolo[3,2-b]pyridine-3-carbonitrile | CHEMBL60343
Type:
Small organic molecule
Emp. Form.:
C12H12N4O
Mol. Mass.:
228.2499
SMILES:
N#Cc1c([nH]c2cccnc12)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: