Reaction Details Report a problem with these data
Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50129051
Substrate
n/a
Meas. Tech.
ChEMBL_212917 (CHEMBL819943)
IC50
<1±n/a nM
Citation
 Duan, JJ; Lu, Z; Xue, CB; He, X; Seng, JL; Roderick, JJ; Wasserman, ZR; Liu, RQ; Covington, MB; Magolda, RL; Newton, RC; Trzaskos, JM; Decicco, CP Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). Bioorg Med Chem Lett 13:2035-40 (2003) [PubMed]  Article 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:
Metalloprotease
Mol. Mass.:
12197.99
Organism:
Sus scrofa (pig)
Description:
Partially purified TACE was obtained from porcine spleen.
Residue:
112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
  
Inhibitor
Name:
BDBM50129051
Synonyms:
CHEMBL64262 | Morpholine-4-carboxylic acid (((S)-hydroxycarbamoyl)-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-methyl)-amide
Type:
Small organic molecule
Emp. Form.:
C28H31N5O6
Mol. Mass.:
533.5756
SMILES:
Cc1cc(COc2ccc(cc2)N2CC[C@H]([C@H](NC(=O)N3CCOCC3)C(=O)NO)C2=O)c2ccccc2n1
Structure:
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