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Target
Methionine--tRNA ligase, cytoplasmic
Ligand
BDBM50129538
Substrate
n/a
Meas. Tech.
ChEMBL_105283 (CHEMBL718950)
IC50
17200±n/a nM
Citation
 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors. Bioorg Med Chem Lett 13:2231-4 (2003) [PubMed]  Article 
Target
Name:
Methionine--tRNA ligase, cytoplasmic
Synonyms:
MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN
Type:
PROTEIN
Mol. Mass.:
101110.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105283
Residue:
900
Sequence:
MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
  
Inhibitor
Name:
BDBM50129538
Synonyms:
5-(3'-Chloro-4'-fluoro-biphenyl-4-yl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid | CHEMBL70536
Type:
Small organic molecule
Emp. Form.:
C22H12Cl3FN2O2
Mol. Mass.:
461.7
SMILES:
OC(=O)c1cc(-c2ccc(cc2)-c2ccc(F)c(Cl)c2)n(n1)-c1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: