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Reaction Details
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TargetCdc25C
LigandBDBM50129574
Substrate/Competitorn/a
Meas. Tech.ChEMBL_49190
IC50 15000±n/a nM
Citation Sohn, JKiburz, BLi, ZDeng, LSafi, APirrung, MCRudolph, J Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones. J Med Chem46:2580-8 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cdc25C
Name:Cdc25C
Synonyms:Dual specificity phosphatase Cdc25C | M-phase inducer phosphatase 3
Type:Substrate
Mol. Mass.:53366.11
Organism:Homo sapiens (Human)
Description:P30307
Residue:473
Sequence:
MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANL
SILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMK
CSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNP
NLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDK
VKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQ
DLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKK
PIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFF
PEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
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  Blast E-value cutoff:
BDBM50129574
n/a
NameBDBM50129574
Synonyms:2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-[1,4]benzoquinone | CHEMBL315754
TypeSmall organic molecule
Emp. Form.C19H17NO4
Mol. Mass.323.3426
SMILESCC(C)=CCc1cccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O |(-1.02,-4.51,;.5,-4.74,;1.06,-6.18,;1.45,-3.53,;2.98,-3.76,;3.94,-2.56,;3.37,-1.13,;4.32,.06,;5.86,-.17,;6.42,-1.59,;7.86,-2.15,;7.79,-3.67,;6.3,-4.06,;5.46,-2.8,;9.17,-1.35,;9.15,.2,;7.79,.97,;10.47,.98,;10.43,2.52,;11.82,.23,;11.84,-1.31,;13.2,-2.08,;10.52,-2.11,;10.52,-3.65,)|
Structure
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