Reaction Details Report a problem with these data
Target
M-phase inducer phosphatase 3
Ligand
BDBM50129574
Substrate
n/a
Meas. Tech.
ChEMBL_49190 (CHEMBL662118)
IC50
15000±n/a nM
Citation
 Sohn, J; Kiburz, B; Li, Z; Deng, L; Safi, A; Pirrung, MC; Rudolph, J Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones. J Med Chem 46:2580-8 (2003) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 3
Synonyms:
CDC25C | Dual specificity phosphatase Cdc25C | M-phase inducer phosphatase 3 | MPIP3_HUMAN
Type:
Substrate
Mol. Mass.:
53366.11
Organism:
Homo sapiens (Human)
Description:
P30307
Residue:
473
Sequence:
MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNPNLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
  
Inhibitor
Name:
BDBM50129574
Synonyms:
2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-[1,4]benzoquinone | CHEMBL315754
Type:
Small organic molecule
Emp. Form.:
C19H17NO4
Mol. Mass.:
323.3426
SMILES:
CC(C)=CCc1cccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O |(-1.02,-4.51,;.5,-4.74,;1.06,-6.18,;1.45,-3.53,;2.98,-3.76,;3.94,-2.56,;3.37,-1.13,;4.32,.06,;5.86,-.17,;6.42,-1.59,;7.86,-2.15,;7.79,-3.67,;6.3,-4.06,;5.46,-2.8,;9.17,-1.35,;9.15,.2,;7.79,.97,;10.47,.98,;10.43,2.52,;11.82,.23,;11.84,-1.31,;13.2,-2.08,;10.52,-2.11,;10.52,-3.65,)|
Structure:
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