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Target
Peptide deformylase, mitochondrial
Ligand
BDBM50131295
Substrate
n/a
Meas. Tech.
ChEBML_154178
IC50
20±n/a nM
Citation
 Davies, SJ; Ayscough, AP; Beckett, RP; Bragg, RA; Clements, JM; Doel, S; Grew, C; Launchbury, SB; Perkins, GM; Pratt, LM; Smith, HK; Spavold, ZM; Thomas, SW; Todd, RS; Whittaker, M Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain. Bioorg Med Chem Lett 13:2709-13 (2003) [PubMed]  Article 
Target
Name:
Peptide deformylase, mitochondrial
Synonyms:
DEFM_HUMAN | PDF | PDF1A | Peptide deformylase mitochondrial | Peptide deformylase, mitochondrial | Polypeptide deformylase
Type:
PROTEIN
Mol. Mass.:
27023.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154318
Residue:
243
Sequence:
MARLWGALSLWPLWAAVPWGGAAAVGVRACSSTAAPDGVEGPALRRSYWRHLRRLVLGPPEPPFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLVQVMRRRRCVGLSAPQLGVPRQVLALELPEALCRECPPRQRALRQMEPFPLRVFVNPSLRVLDSRLVTFPEGCESVAGFLACVPRFQAVQISGLDPNGEQVVWQASGWAARIIQHEMDHLQGCLFIDKMDSRTFTNVYWMKVND
  
Inhibitor
Name:
BDBM50131295
Synonyms:
(S)-2-[(R)-2-Ethylsulfanylmethyl-3-(formyl-hydroxy-amino)-propionylamino]-3,3,N,N-tetramethyl-butyramide | CHEMBL91835
Type:
Small organic molecule
Emp. Form.:
C15H29N3O4S
Mol. Mass.:
347.473
SMILES:
CCSC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C
Structure:
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