Reaction Details Report a problem with these data
Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50132337
Substrate
n/a
Meas. Tech.
ChEBML_202617
IC50
40000±n/a nM
Citation
 Sundaramoorthi, R; Shakespeare, WC; Keenan, TP; Metcalf, CA; Wang, Y; Mani, U; Taylor, M; Liu, S; Bohacek, RS; Narula, SS; Dalgarno, DC; van Schravandijk, MR; Violette, SM; Liou, S; Adams, S; Ram, MK; Keats, JA; Weigle, M; Sawyer, TK; Weigele, M Bone-targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues. Bioorg Med Chem Lett 13:3063-6 (2003) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50132337
Synonyms:
CHEMBL101795 | [(4-{4-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-benzoylamino}-phenyl)-phosphono-methyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C27H25N5O8P2
Mol. Mass.:
609.4636
SMILES:
COc1cccc(c1)-c1cn(-c2ccc(cc2)C(=O)Nc2ccc(cc2)C(P(O)(O)=O)P(O)(O)=O)c2ncnc(N)c12
Structure:
Search PDB for entries with ligand similarity: