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Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50132581
Substrate
n/a
Meas. Tech.
ChEMBL_196750 (CHEMBL803331)
EC50
8713±n/a nM
Citation
 Gernert, DL; Ajamie, R; Ardecky, RA; Bell, MG; Leibowitz, MD; Mais, DA; Mapes, CM; Michellys, PY; Rungta, D; Reifel-Miller, A; Tyhonas, JS; Yumibe, N; Grese, TA Design and synthesis of fluorinated RXR modulators. Bioorg Med Chem Lett 13:3191-5 (2003) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50132581
Synonyms:
(2E,4Z,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-5-fluoro-3-methyl-octa-2,4,6-trienoic acid | CHEMBL110921
Type:
Small organic molecule
Emp. Form.:
C25H33F3O3
Mol. Mass.:
438.5229
SMILES:
C\C(=C/C(O)=O)\C=C(/F)\C=C(\C)c1cc(cc(c1OCC(F)F)C(C)(C)C)C(C)(C)C
Structure:
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