Target
TGF-beta receptor type-1
Ligand
BDBM50132978
Substrate
n/a
Meas. Tech.
ChEMBL_123678 (CHEMBL728561)
IC50
>9000±n/a nM
Citation
 Sawyer, JSAnderson, BDBeight, DWCampbell, RMJones, MLHerron, DKLampe, JWMcCowan, JRMcMillen, WTMort, NParsons, SSmith, ECVieth, MWeir, LCYan, LZhang, FYingling, JM Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. J Med Chem 46:3953-6 (2003) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50132978
Synonyms:
2-(4-Phenyl-1H-pyrazol-3-yl)-pyridine | 2-(4-phenyl-1H-pyrazol-3-yl)pyridine | CHEMBL129280
Type:
Small organic molecule
Emp. Form.:
C14H11N3
Mol. Mass.:
221.2572
SMILES:
c1[nH]nc(c1-c1ccccc1)-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: