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Target
TGF-beta receptor type-1
Ligand
BDBM50132977
Substrate
n/a
Meas. Tech.
ChEMBL_208101 (CHEMBL814457)
IC50
543±n/a nM
Citation
 Sawyer, JS; Anderson, BD; Beight, DW; Campbell, RM; Jones, ML; Herron, DK; Lampe, JW; McCowan, JR; McMillen, WT; Mort, N; Parsons, S; Smith, EC; Vieth, M; Weir, LC; Yan, L; Zhang, F; Yingling, JM Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. J Med Chem 46:3953-6 (2003) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50132977
Synonyms:
2-Methyl-6-(4-phenyl-1H-pyrazol-3-yl)-pyridine | CHEMBL129553
Type:
Small organic molecule
Emp. Form.:
C15H13N3
Mol. Mass.:
235.2838
SMILES:
Cc1cccc(n1)-c1n[nH]cc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: