Reaction Details Report a problem with these data
Target
Retinoic acid receptor, alpha, isoform CRA_b
Ligand
BDBM50133126
Substrate
n/a
Meas. Tech.
ChEMBL_195190 (CHEMBL802723)
Ki
1399±n/a nM
Citation
 Michellys, PY; Ardecky, RJ; Chen, JH; D'Arrigo, J; Grese, TA; Karanewsky, DS; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Montrose-Rafizadeh, C; Ogilvie, KM; Reifel-Miller, A; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. J Med Chem 46:4087-103 (2003) [PubMed]  Article 
Target
Name:
Retinoic acid receptor, alpha, isoform CRA_b
Synonyms:
Retinoic acid receptor alpha
Type:
PROTEIN
Mol. Mass.:
50955.52
Organism:
Rattus norvegicus
Description:
ChEMBL_195190
Residue:
459
Sequence:
MYESVEVGGLAPAPNPFLVVDFYNQNRACLLQEKGLPAPGPYSTPLRTPLWNGSNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDKVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQSGGGTRDGGGLAPPPGSCSPSLSPSSHRSSPATQSP
  
Inhibitor
Name:
BDBM50133126
Synonyms:
5-[2-(3,5-Diisopropyl-2-propoxy-phenyl)-cyclopent-1-enyl]-3-methyl-penta-2,4-dienoic acid | CHEMBL133176
Type:
Small organic molecule
Emp. Form.:
C26H36O3
Mol. Mass.:
396.5622
SMILES:
CCCOc1c(cc(cc1C1=C(CCC1)\C=C\C(\C)=C\C(O)=O)C(C)C)C(C)C |t:11|
Structure:
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