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Target
Falcipain 2
Ligand
BDBM50133619
Substrate
n/a
Meas. Tech.
ChEBML_69692
IC50
9400±n/a nM
Citation
 Chiyanzu, I; Hansell, E; Gut, J; Rosenthal, PJ; McKerrow, JH; Chibale, K Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett 13:3527-30 (2003) [PubMed]  Article 
Target
Name:
Falcipain 2
Synonyms:
Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:
Enzyme
Mol. Mass.:
55912.60
Organism:
Plasmodium falciparum
Description:
Recombinant falcipain-2.
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50133619
Synonyms:
(3Z)-5-chloro-7-methyl-1H-indole-2,3-dione 3-thiosemicarbazone | CHEMBL118355
Type:
Small organic molecule
Emp. Form.:
C10H9ClN4OS
Mol. Mass.:
268.723
SMILES:
Cc1cc(Cl)cc2c(N=NC(N)=S)c(O)[nH]c12 |w:9.9|
Structure:
Search PDB for entries with ligand similarity: