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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50134350
Substrate
n/a
Meas. Tech.
ChEBML_37595
IC50
>250000±n/a nM
Citation
 Senior, SJ; Illarionov, PA; Gurcha, SS; Campbell, IB; Schaeffer, ML; Minnikin, DE; Besra, GS Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme. Bioorg Med Chem Lett 13:3685-8 (2003) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH) | 3-oxoacyl-[acyl-carrier-protein] synthase III | FABH_MYCTU | fabH
Type:
Enzyme
Mol. Mass.:
34865.07
Organism:
Mycobacterium tuberculosis
Description:
P9WNG3
Residue:
335
Sequence:
MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
  
Inhibitor
Name:
BDBM50134350
Synonyms:
5-Benzyl-4-hydroxy-3,5-dimethyl-5H-thiophen-2-one | 5-benzyl-3,5-dimethyl-4-hydroxy-5H-thiophen-2-one | CHEMBL123876
Type:
Small organic molecule
Emp. Form.:
C13H14O2S
Mol. Mass.:
234.314
SMILES:
CC1C(=O)SC(C)(Cc2ccccc2)C1=O
Structure:
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