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Target
Cycloartenol-C-24-methyltransferase
Ligand
BDBM50134734
Substrate
n/a
Meas. Tech.
ChEMBL_203192 (CHEMBL804437)
IC50
>100000±n/a nM
Citation
 Magaraci, F; Jimenez, CJ; Rodrigues, C; Rodrigues, JC; Braga, MV; Yardley, V; de Luca-Fradley, K; Croft, SL; de Souza, W; Ruiz-Perez, LM; Urbina, J; Gonzalez Pacanowska, D; Gilbert, IH Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi. J Med Chem 46:4714-27 (2003) [PubMed]  Article 
Target
Name:
Cycloartenol-C-24-methyltransferase
Synonyms:
24-sterol C-methyltransferase | CPH | SMT1 | SMT1_ARATH
Type:
PROTEIN
Mol. Mass.:
38266.01
Organism:
Arabidopsis thaliana
Description:
ChEMBL_415082
Residue:
336
Sequence:
MDLASNLGGKIDKSDVLTAVEKYEQYHVFHGGNEEERKANYTDMVNKYYDLATSFYEYGWGESFHFAQRWKGESLRESIKRHEHFLALQLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENSFDAVYAIEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMTDAFDPDNAEHQKIKGEIEIGDGLPDIRLTTKCLEALKQAGFEVIWEKDLAKDSPVPWYLPLDKNHFSLSSFRLTAVGRFITKNMVKILEYIRLAPQGSQRVSNFLEQAAEGLVDGGRREIFTPMYFFLARKPE
  
Inhibitor
Name:
BDBM50134734
Synonyms:
1-[(3S,10S,17S)-3-(tert-Butyl-dimethyl-silanyloxy)-10-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-1-(3-chloro-pyridin-4-yl)-ethanol | CHEMBL145672
Type:
Small organic molecule
Emp. Form.:
C31H50ClNO2Si
Mol. Mass.:
532.273
SMILES:
CC(C)(C)[Si](C)(C)O[C@H]1CC[C@@]2(C)C(CCC3C4CC[C@@H](C4CCC23)C(C)(O)c2ccncc2Cl)C1
Structure:
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