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Target
Protein phosphatase 1B
Ligand
BDBM50135698
Substrate
n/a
Meas. Tech.
ChEBML_161756
IC50
>100000±n/a nM
Citation
 Gulledge, BM; Aggen, JB; Eng, H; Sweimeh, K; Chamberlin, AR Microcystin analogues comprised only of Adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors. Bioorg Med Chem Lett 13:2907-11 (2003) [PubMed]  Article 
Target
Name:
Protein phosphatase 1B
Synonyms:
PP2C-beta | PP2CB | PPM1B | PPM1B_HUMAN | Protein phosphatase 1B | Protein phosphatase 2C beta | Protein phosphatase 2C isoform beta
Type:
PROTEIN
Mol. Mass.:
52620.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_161756
Residue:
479
Sequence:
MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRLAKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI
  
Inhibitor
Name:
BDBM50135698
Synonyms:
(R)-2-((4E,6E)-(2S,3S)-3-Acetylamino-2,6-dimethyl-10-phenyl-deca-4,6-dienoylamino)-propionic acid | CHEMBL97878
Type:
Small organic molecule
Emp. Form.:
C23H32N2O4
Mol. Mass.:
400.5112
SMILES:
C[C@@H](NC(=O)[C@@H](C)[C@@H](NC(C)=O)\C=C\C(\C)=C\CCCc1ccccc1)C(O)=O
Structure:
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