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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50135777
Substrate
n/a
Meas. Tech.
ChEMBL_153537 (CHEMBL765406)
IC50
15±n/a nM
Citation
 Xu, Y; Mayhugh, D; Saeed, A; Wang, X; Thompson, RC; Dominianni, SJ; Kauffman, RF; Singh, J; Bean, JS; Bensch, WR; Barr, RJ; Osborne, J; Montrose-Rafizadeh, C; Zink, RW; Yumibe, NP; Huang, N; Luffer-Atlas, D; Rungta, D; Maise, DE; Mantlo, NB Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. J Med Chem 46:5121-4 (2003) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50135777
Synonyms:
2-(4-{3-[1-(4-tert-Butyl-benzyl)-4-methyl-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-propyl}-phenoxy)-2-methyl-propionic acid | CHEMBL148639
Type:
Small organic molecule
Emp. Form.:
C27H35N3O4
Mol. Mass.:
465.5845
SMILES:
Cn1c(CCCc2ccc(OC(C)(C)C(O)=O)cc2)nn(Cc2ccc(cc2)C(C)(C)C)c1=O
Structure:
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