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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50135775
Substrate
n/a
Meas. Tech.
ChEMBL_153860 (CHEMBL762589)
EC50
3000±n/a nM
Citation
 Xu, Y; Mayhugh, D; Saeed, A; Wang, X; Thompson, RC; Dominianni, SJ; Kauffman, RF; Singh, J; Bean, JS; Bensch, WR; Barr, RJ; Osborne, J; Montrose-Rafizadeh, C; Zink, RW; Yumibe, NP; Huang, N; Luffer-Atlas, D; Rungta, D; Maise, DE; Mantlo, NB Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. J Med Chem 46:5121-4 (2003) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50135775
Synonyms:
2-Methyl-2-(4-{3-[1-(4-methyl-benzyl)-5-oxo-4-propyl-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-propyl}-phenoxy)-propionic acid | CHEMBL149676
Type:
Small organic molecule
Emp. Form.:
C26H33N3O4
Mol. Mass.:
451.5579
SMILES:
CCCn1c(CCCc2ccc(OC(C)(C)C(O)=O)cc2)nn(Cc2ccc(C)cc2)c1=O
Structure:
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